Title: Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes

Authors (13): E. Lythell, R. Suardíaz, P. Hinchliffe, C. Hanpaibool, S. Visitsatthawong, A. S. F. .Oliveira, E. J. M. .Lang, P. Surawatanawong, V. S. Lee, T. Rungrotmongkol, N. Fey, J. Spencer, A. J. Mulholland

Themes: Biocatalysis (2020)

DOI: 10.1039/d0cc02520h

Citations: 10

Pub type: journal-article

Publisher: Royal Society of Chemistry (RSC)

Issue: 50

License: [{"start"=>{"date-parts"=>[[2021, 5, 6]], "date-time"=>"2021-05-06T00:00:00Z", "timestamp"=>1620259200000}, "content-version"=>"am", "delay-in-days"=>491, "URL"=>"http://rsc.li/journals-terms-of-use"}]

Publication date(s): 2020/06/23 (print) 2020 (online)

Pages: 6874-6877

Volume: 56 Issue: 50

Journal: Chemical Communications

Link: [{"URL"=>"http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC02520H", "content-type"=>"unspecified", "content-version"=>"vor", "intended-application"=>"similarity-checking"}]

URL: http://dx.doi.org/10.1039/d0cc02520h

Simulations show the mono-zinc form of MCR to be stable and competent for covalent phospho(ethanolamine) intermediate formation.

Name Description Publised
6SUT Crystal structure of phosphothreonine MCR-2 Related Article: Resistance to the “Last Resort” Antibiotic Colistin: A ... 2020
SI for: Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes Related Article: Lythell, Emily, Suardíaz, Reynier, Hinchliffe, Philip, ... 2020


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